Aldoxime-substituted triazolium compounds useful in the treatment of poisoning by phosphorus-containing chemicals
US4865837A · kind A · utility
8Cited by
2References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1987 |
| Grant date | Sep 12, 1989 |
| Priority date | — |
| Expiry date | Jul 28, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A therapeutically effective class of low toxicity aldoxime-substituted trazolium derivatives is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these low toxicity aldoxime-substituted triazolium derivatives has been found to save mice having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.
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