Method for the delivery of genetic material across the blood brain barrier
US4866042A · kind A · utility
107Cited by
6References
6Claims
0Family size
Inventor
Key dates
| Filing date | Nov 18, 1987 |
| Grant date | Sep 12, 1989 |
| Priority date | — |
| Expiry date | Nov 18, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating genetic and acquired brain disorders is disclosed in which genetic material is introduced into the blood stream for delivery to the brain. Prior to delivery, the interendothelial structure of the BBB is chemically altered to permit passage of the genetic material therethrough. This is accomplished through osmotic disruption of the BBB by administration This invention was made with Government support under a grant from the Veterans Administration. The Government has certain rights in this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.