Topsentin compounds effective against viruses and certain tumors

US4866084A · kind A · utility

Assignee

• Harbor Branch Oceanographic Institution, Inc. · US

Inventors

• Sarath P. Gunasekera · Vero Beach, US
• Sue S. Cross · Fort Pierce, US
• Yoel Kashman · Nes Ziona, IL
• May S. Lui · Winter Garden, US
• Kenneth L. Rinehart · Urbana, US
• Shinji Tsujii · Kamakura, JP

Key dates

• Filing date: Dec 19, 1988
• Grant date: Sep 12, 1989
• Expiry date: Dec 19, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing the compounds and methods of using them are disclosed. This new class of compounds has the generic formula: ##STR1## R.sup.1-8 are the same or different selected from --H, --OH, halogen, --R, --OR, --OCOR, or --OA; PA1 Y is the single group --O, or two groups, same or different, selected from --H, --OH, --OR, or --OCOR with the provision that Y shall not be two --OH groups; PA1 Z are the same or different selected from --H, --R; PA1 R is C1-5 alkyl and A is --R--phenyl. The compounds are antiviral agents and antitumor agents which are effective against specific tumors.