Patent · US Expired

1,4-dihydropyridine derivatives with calcium agonist and alpha.sub.1 -antagonist activity

US4868181A · kind A · utility

3Cited by

6References

72Claims

0Family size

Assignee

E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

Alexander L. Johnson · Wilmington, US
Philip Ma · Mountain View, US
Petrus B. M. W. M. Timmermans · Kennett Square, US
Ruth R. Wexler · Chadds Ford, US

Key dates

Filing date	Jun 30, 1987
Grant date	Sep 19, 1989
Priority date	—
Expiry date	Jun 30, 2007

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D491/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha.sub.1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the formula: ##STR1## wherein Ar, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined in the specification.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.