Styryl tetrazoles and anti-allergic use thereof
US4868193A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 24, 1986 |
| Grant date | Sep 19, 1989 |
| Priority date | — |
| Expiry date | Sep 24, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## and salts thereof, wherein, PA1 Ar.sub.1 is phenyl, naphthyl or heterocyclic ring selected from the group consisting of quinolinyl, isoquinolinyl, pyridinyl, quinazolinyl, quinoxalinyl, benzimidazolyl, 1,2,3,4-tetrahydroquinolinyl or 1,2,3,4-tetrahydroquinoxalinyl; PA1 R.sub.1 is hydrogen, alkyl, carboxy, carbalkoxy, alkanoyl, formyl, nitrilo, amino, halo, CF.sub.3, hydroxy, alkoxy, aralkoxy, aryloxy, nitro, sulfanyl, mercapto or alkylthio; PA1 R.sub.2 is hydrogen, alkyl or Ar.sub.1, PA1 n is 1 or 2 PA1 X is O, S, or NH-- PA1 Y is a bond, methylene or ethylene PA1 R.sub.3 and R.sub.4 are independently hydrogen, alkyl or halo PA1 Ar is phenyl, naphthyl, pyridyl or quinolinyl containing one or two substituents selected from the group consisting of hydrogen, alkoxy, aryloxy, hydroxy, hydroxyalkyl, alkyl, aryl, halo, CF.sub.3, carboxy, carbalkoxy, lower acyl, nitrilo, amino, nitro, mercapto or alkylthio possess anti-inflammatory and anti-allergic activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.