Process for the preparation of cefodizime

US4868295A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Ottmar Jaenicke · Kelkheim, DE
• Hans Wagner · Rockenberg, DE
• Manfred Worm · Wiesbaden, DE

Key dates

• Filing date: Dec 1, 1986
• Grant date: Sep 19, 1989
• Expiry date: Dec 1, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of cefodizime of the formula ##STR1## wherein (a) a compound of the formula II (ATS) ##STR2## wherein R.sub.1 represents hydrogen or an aminoprotective group and A represents a hydrogen atom or one equivalent of an alkali metal or alkaline earth metal, of ammonium or of an organic nitrogen base, is first reacted with a compound of the formula III EQU R--SO.sub.2 Hal PA0 wherein R represents an optionally substituted alkyl, aryl or aralkyl radical and Hal represents a halogen atom, in an organic solvent and, if appropriate, in the presence of a base, PA0 (b) a compound of the formula I (TACS) ##STR3## in which A has the above meaning, is reacted with a silylating agent in an organic solvent and, if appropriate, in the presence of a base, and PA0 (c) the two products formed in (a) and (b) are reacted in their reaction solutions, and any protective group R.sub.1 present in the end product of the formula I is eliminated.