Method of selectively inhibiting HIV
US4869903A · kind A · utility
20Cited by
4References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 8, 1988 |
| Grant date | Sep 26, 1989 |
| Priority date | — |
| Expiry date | Apr 8, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/415
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting HIV replication in and cellular proliferation of HIV-infected cells. The infected cells are exposed to a single-chain ribosome inactivating protein, at a protein concentration and for an exposure period sufficient to produce a substantial reduction in (a) the level of HIV antigen or reverse transcriptase associated with the infected cells, (b) the ratio of viability of infected/uninfected T cells, and/or (c) the ratio of HIV antigen/cellular antigen in infected macrophages. The method is used to treat HIV infection in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.