Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
US4870023A · kind A · utility
46Cited by
2References
51Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 8, 1988 |
| Grant date | Sep 26, 1989 |
| Priority date | — |
| Expiry date | Feb 8, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/826
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to recombinant baculoviruses which encode fusion polyhedrin proteins capable of forming occlusion bodies containing foreign peptides. The recombinant baculoviruses of the invention are formed by insertion into or replacement of regions of the polyhedrin gene that are not essential for occlusion body formation, with foreign DNA fragments by recombinant DNA techniques. The recombinant occlusion bodies produced in accordance with the present invention have uses in vaccine formulations, immunoassays, immobilized enzyme reactions, as biological insecticides, and as expression vectors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.