11.beta.-alkynyl-estrenes and -estradienes, their production and pharmaceutical preparations containing them

US4870069A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Eckhard Ottow · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Guenter Neef · Berlin, DE
• Juergen Bardenhagen · Aachen, DE
• Sybille Beier · Berlin, DE
• Walter Elger · Berlin, DE
• David Henderson · Berlin, DE

Key dates

• Filing date: Jan 25, 1988
• Grant date: Sep 26, 1989
• Expiry date: Jan 25, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/001
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

11.beta.-substituted steroids of the formula ##STR1## wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; PA1 X is O, two H atoms or hydroximino; PA1 Z is the residue of a pentagonal or hexagonal ring which is optionally substituted and optionally saturated; PA1 R.sup.1 is vinyl, C.sub.3-7 -cyclo-1-alkenyl, phenyl, naphthyl or 5- or 6-membered heterocyclic aromatic having at least one N, O or S atom, each being unsubstituted or substituted by 1-3 halogen atoms, 1-3 C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, C.sub.1-4 -acyl, C.sub.2-10 -alkenyl, C.sub.1-4 -acyloxy, phenyl, nitro, hydroxy, carboxy, cyanide, COOR.sup.4 or amino optionally substituted by 1-2 C.sub.1-4 -alkyl; PA1 R.sup.2 is methyl or ethyl, PA1 R.sup.3 is H, Cl or methyl; and PA1 R.sup.4 is C.sub.1-4 -alkyl optionally substituted by phenyl which itself is optionally substituted by C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, halogen or phenyl have valuable pharmacological properties.