Sulphonamidoethyl compounds, pharmaceutical compositions comprising these compounds and processes for preparing them

US4870076A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Armin Heckel · Biberach an der Riß, DE
• Josef Nickl
• Erich Muller · Zell am Harmersbach, DE
• Berthold Narr · Biberach, DE
• Johannes Weisenberger · Biberach, DE
• Wolfgang Eisert · Biberach, DE
• Thomas Müller · Biberach, DE

Key dates

• Filing date: Sep 3, 1987
• Grant date: Sep 26, 1989
• Expiry date: Sep 3, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R.sub.1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R.sub.2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydro-pyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C.sub.1 -C.sub.3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.