Tryptamine derivatives active on central nervous system

US4870085A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Thomas Glaser · Overath, DE
• Siegfried Raddatz · Hanerau-Hademarschen, DE
• Jorg Traber · Lohmar, DE

Key dates

• Filing date: Mar 30, 1988
• Grant date: Sep 26, 1989
• Expiry date: Mar 30, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel tryptamines of the formula ##STR1## in which X is an alkylene chain or 2 to 4 carbon atoms wherein a carbon atom may be replaced by O or N-lower alkyl, and wherein a carbon atoms may be substituted by lower alkyl, PA0 R is hydrogen, lower alkyl, lower alkoxy, phenyl-lower alkyl, phenyl-lower alkoxy, hydroxy, amino-lower alkyl, fluorine, chlorine, bromine, cyano, carbamoyl or azido, PA0 R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently is hydrogen or lower alkyl, PA0 R.sup.5 is hydrogen, R.sup.6 --CO-- or R.sup.6 --SO.sub.2 --, and PA0 R.sup.6 is amino, lower alkoxy, phenyl or lower alkyl-phenyl, or dimers or salts thereof, are effective in treating disorders of the central nervous system.