1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivatives, and their fungicidal use thereof

US4870088A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Ernst Blume · Hachenburg, DE
• Wolfgang Schaper · Diedorf, DE
• Heinz Ehrhardt · Rehling, DE
• Wolfgang Raether
• Walter Dittmar · Hofheim, DE
• Heinz Hanel · Oberursel, DE
• Burkhard Sachse · Kelkheim, DE

Key dates

• Filing date: Mar 13, 1987
• Grant date: Sep 26, 1989
• Expiry date: Mar 13, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides. They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent). The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.