Conjugates of vinblastine, a process for their preparation and their use in therapy
US4870162A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1986 |
| Grant date | Sep 26, 1989 |
| Priority date | — |
| Expiry date | Apr 23, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6805
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new conjugates of vinblastine and some of its known derivatives with proteins, fragments thereof, aminoacids or amines, which are useful as anti-tumor agents. The invention also relates to some intermediates which are active in chemotherapy, and amino derivatives thereof. These compounds correspond to the following general formula ##STR1## in which A represents an acetylamino-, trifluoroacetylamino- or carbobenzyloxyamino- substituted --CO(CH.sub.2).sub.n CO-- or ##STR2## in which n is 1 to 5, R.sub.1 represents an optionally modified protein radical, PA1 R.sub.2 represents a methoxy group, an amino group or an alpha-aminoacid ester radical which is bonded via a bond of the amide type and in which the ester group contains 1 to 6 carbon atoms, and R.sub.3 represents hydrogen or hydroxyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.