No-carrier-added [.sup.18 F]-N-fluoroalkylspiroperidols
US4871527A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1987 |
| Grant date | Oct 3, 1989 |
| Priority date | — |
| Expiry date | Apr 29, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed radioligands labeled with the position emitting radionuclide [.sup.18 F] suitable for dynamic study in living humans with position emission transaxial tomography. These new [.sup.18 F]-N-fluoroalkylspiroperidols, wherein the alkyl group contains from 2-6 carbon atoms, exhibit extremely high affinity for the dopamine receptors and provide enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to make these new radioligands useful for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for these radioligands as well as a new procedure for preparing the radiolabeled alkyl halide alkylating reagents are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.