Naphthyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

US4871735A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Joachim Heider · Warthausen, DE
• Manfred Psiorz · Ingelheim am Rhein, DE
• Andreas Bomhard · Biberach, DE
• Norbert Hauel · Schemmerhofen, DE
• Berthold Narr · Biberach, DE
• Klaus Noll · Cologne, DE
• Christian Lillie · Wien, AT
• Walter Kobinger · Wien, AT
• Jurgen Dammgen · Sulmingen, DE

Key dates

• Filing date: Sep 11, 1987
• Grant date: Oct 3, 1989
• Expiry date: Sep 11, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new naphthyl derivatives of general formula ##STR1## wherein N represents the number 1 or 2, PA0 A represents a --CH.sub.2 --, --CO--, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## while the atom marked with an x is linked to the phenyl nucleus, E represents a straight chained alkylene group optionally substituted by an alkyl group, PA0 G represents a straight chained alkylene group optionally substituted by an alkyl group, PA0 L represents a bond or an oxygen atom, if G represents a straight chained alkylene group with 2 to 5 carbon atoms optionally substituted by an alkyl group, PA0 R.sub.1 and R.sub.2, which may be identical or different, represent alkyl or alkoxy groups or R.sub.1 and R.sub.2 together represent an alkylenedioxy group, PA0 R.sub.3 represents a hydrogen atom, or an alkyl or an allyl group, PA0 R.sub.4, R.sub.5 and R.sub.6, which may be identical or different, represent hydrogen atoms, alkyl or alkoxy groups, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, particularly a heart rate lowering activity. The new compounds may be prepared using methods known per se.