L-glutamic acid derivatives

US4871743A · kind A · utility

Assignees

• THE TRUSTEES OF PRINCETON UNIVERSITY · US
• ELI LILLY AND COMPANY · US

Inventors

• Edward C. Taylor · Princeton, US
• Philip M. Harrington · Cranbury, US
• Chuan Shih · Carmel, US

Key dates

• Filing date: Jan 19, 1988
• Grant date: Oct 3, 1989
• Expiry date: Jan 19, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/545
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-(4-[4-(2,4-diamino-6-hydroxypyrimidin-5-yl)-butyl]-benzoyl)-L-glutamic acid.