N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzo yl]glutamic acid derivatives as neoplastic growth inhibitors
US4871746A · kind A · utility
15Cited by
1References
11Claims
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Key dates
| Filing date | May 31, 1988 |
| Grant date | Oct 3, 1989 |
| Priority date | — |
| Expiry date | May 31, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-[N-(Tetrahydropyrido[2,3-d]pyrimidinylmethyl) aminomethylbenzoyl]glutamic acid derivatives are antineoplastic agents with an effect on one or more enzymes which utilize metabolic derivatives of folic acid. The compounds can be prepared by allowing a protected aminomethylbenzoylglutamic acid derivative to react with 2-amino-4-hydroxy-6-formylpyrido[2,3-d]pyrimidine, reducing the intermediate Schiff base, and subjecting the intermediate to catalytic hydrogenation. A typical embodiment is (S,S) N-[N-(2-amino-4-hydroxy-5,6,7,8- tetrahydropyrido-[2,3-d]pyrimidin-6-ylmethyl)-4-aminomethylbenzoyl]-glutam ic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.