Process for separating and producing chlorogenic acid

US4872987A · kind A · utility

Assignee

• Ergo Forschungsgesellschaft mbH · DE

Inventors

• Reiner Kopsch · Schenefeld, DE
• Claus F. Gosswein · Kürten, DE
• Henning Lutz · Halstenbek, DE
• Michael Ball · Santa Monica, US
• Peter Hubert · Lemwerder, DE

Key dates

• Filing date: Mar 20, 1989
• Grant date: Oct 10, 1989
• Expiry date: Mar 20, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/757
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Chlorogenic acid can be separated and produced as free acid or as salts thereof from plant raw material extracts by means of gel permeation chromatography on cross-linked modified polysaccharides, especially on dextrans. To obtain the free acid, the aqueous extract must be adjusted to a pH in the range of about 2 to 2.8. By use of a column of sufficient length the isomeric 5-, 4- and 3-chlorogenic acid can also be separated by the process of the invention.