Method of synthesizing leukotriene B.sub.4 and derivatives thereof
US4873024A · kind A · utility
2Cited by
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11Claims
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Key dates
| Filing date | Mar 8, 1988 |
| Grant date | Oct 10, 1989 |
| Priority date | — |
| Expiry date | Mar 8, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved method for synthesizing leukotriene B.sub.4 and derivatives thereof is disclosed, as are novel intermediates used in the process. Unlike prior art processes, the method of this invention involves a step in which 2(R)-[[(1,1-dimethylethyl)diphenylsilyl)]oxy]dec-4(Z)-ene-1-ol or a related compound is coupled with methyl-[5(S)-[[1,1dimethylethyl)-diphenylsilyl]oxy]-dec-8(E)-10-(dimethylp hosphono)-6-ynoate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.