Liposome drug delivery method and composition
US4873088A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 13, 1987 |
| Grant date | Oct 10, 1989 |
| Priority date | — |
| Expiry date | Jul 13, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1272
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for enhancing the therapeutic effectiveness of adriamycin, in the treatment of cancer, is disclosed. Liposomes containing coentrapped adriamycin and a secondary compound effective to reduce the toxicity of adriamycin or enhance the induction by adriamycin of the tumoricidal activity of host lymphoid cells, such as lipopolysaccharide, are administered parenterally in a therapeutically effective dose. In another aspect, macrophages stimulated in vivo with liposomes containing entrapped liposomes are exposed to an immunostimulator, for enhanced tumoricidal activity. Also disclosed are liposome compositions containing coentrapped adriamycin and an immunostimulator.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.