Isolation and structural elucidation of cephalostatins 1-4
US4873245A · kind A · utility
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Key dates
| Filing date | Mar 14, 1988 |
| Grant date | Oct 10, 1989 |
| Priority date | — |
| Expiry date | Mar 14, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The marine worm Cephalodiscus gilchristi (Hemichordata phylum) from Southeast Africa has been found to contain powerful inhibitors of the murine P388 lymphocytic leukemia, herein denominated "cephalostatin 1, cephalostatin 2, cephalostatin 3 and cephalostatin 4". Pharmaceutical preparations containing the substances and methods of use are described. Cephalostatin 1-3 having the following structure: ##STR1## whereas cephalostatin 4 is an oxy- derivative of cephalostatin 2, having oxygen interposed in the 14-15 double bond as shown below: ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.