Process for the preparation of the demalonyl compound of macrolide lactones

US4873347A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Peter Hammann · Kelkheim, DE
• Susanne Grabley · Königstein, DE
• Wolfgang Raether
• Bernd Ciommer · Kelkheim, DE
• Heinz Kluge · Hofheim, DE
• Burkhard Sachse · Kelkheim, DE

Key dates

• Filing date: Dec 22, 1987
• Grant date: Oct 10, 1989
• Expiry date: Dec 22, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/01
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

It is possible to prepare the demalonyl compound of macrolide lactones by hydrolysis in the presence of a base without a retro-aldol cleavage occurring.