Process for the preparation of 3-(4'-bromobiphenyl-4-yl)tetralin-1-one
US4873363A · kind A · utility
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Key dates
| Filing date | May 11, 1988 |
| Grant date | Oct 10, 1989 |
| Priority date | — |
| Expiry date | May 11, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C49/697
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new process for the preparation of a 3-(4'-bromobiphenyl-4-yl)tetralin-1-one known as a key intermediate for the production of rodenticides and clinical medicines is provided. The title compound is prepared from P-bromobiphenylbenzylketone in three steps, wherein one of key inventions is dehydroxylation of 3-(4'-bromobiphenyl)-3-hydroxy-4-phenylbutyric acid ethyl ester using trialkylsilane in trifluoroacetic acid. This new process offers a high yield with a facile way and is more suitable for a commercial production than the prior art methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.