1,4-Disubstituted piperazines having dopaminergic activity
US4874765A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1987 |
| Grant date | Oct 17, 1989 |
| Priority date | — |
| Expiry date | Apr 22, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/088
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and stand for hydrogen or halogen or a trihalomethyl, lower alkyl, lower alkoxy, nitro, hydroxyl, aralkyloxy or an 1-(2-propenyl-4-piperazinyl) group; PA1 R.sub.5 stands for hydrogen or a C.sub.1-4 alkyl group; PA1 R.sub.6 represents a C.sub.3-6 alkyl, alkenyl, alkynyl group or a ##STR2## group, wherein R.sub.7 means a C.sub.2-5 alkyl, alkenyl or alkinyl group; and PA1 is 2 or 3, PA1 with the provisos that: PA1 R.sub.6 is different from isopropyl, n-butyl and isobutyl group when R.sub.2, R.sub.3, R.sub.4 and R.sub.5 stand for hydrogen, R.sub.1 means 2-chloro and n is 2; PA1 R.sub.6 is different from isopropyl group when R.sub.2, R.sub.3, R.sub.4 and R.sub.5 stand for hydrogen, R.sub.1 means 2-chloro and n is 2; or when R.sub.2, R.sub.3, R.sub.4 and R.sub.5 stand for hydrogen, R.sub.1 means 2-methyl group and n is 2; and PA1 R.…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.