Process for the preparation of methylene derivatives of androsta-1,4-diene-3,17-dione
US4876045A · kind A · utility
12Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 1988 |
| Grant date | Oct 24, 1989 |
| Priority date | — |
| Expiry date | Sep 12, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J1/0022
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a new process for the preparation of known aromatase inhibitors of the following formula ##STR1## wherein each of R.sub.1 and R.sub.3, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl; PA0 R.sub.2 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl and PA0 R.sub.4 is hydrogen or fluorine; the process comprising subjecting to Mannich reaction a compound of formula ##STR2## wherein R.sub.1,R.sub.2,R.sub.3 and R.sub.4 are as defined above, and then oxidizing the respective 6-methylene derivative thus obtained by methods known per se.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.