Circulation-active substituted 5-nitro-1,4-dihydropyridines

US4876254A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerhard Franckowiak · Wuppertal, DE
• Michael Kayser · Hagen, DE
• Matthias Schramm · Cologne, DE
• Gunther Thomas · Wuppertal, DE
• Rainer Gross · Wuppertal, DE
• Elisabeth Perzborn · Wuppertal, DE
• Friedel Seuter

Key dates

• Filing date: Apr 8, 1988
• Grant date: Oct 24, 1989
• Expiry date: Apr 8, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For the treatment of circulation disorders, the novel 5-nitro-1,4-dihydropyridines of the formula ##STR1## in which R represents C.sub.6 -C.sub.14 -aryl which can be mono- to pentasubstituted by identical or different substituents from the series comprising halogen, nitro, cyano, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, trifluoromethyl, trifluoromethoxy, difluoromethoxy, trifluoromethylthio and benzyl, benzyloxy or benzylthio optionally substituted by nitro, cyano, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, or PA1 represents a heterocycle from the series pyrryl, thienyl, furyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidyl, quinolyl, benzoxadiazolyl, chromenyl or thiochromenyl optionally mono- to tetrasubstituted by halogen, phenyl or C.sub.1 -C.sub.4 -alkyl or PA1 represents straight-chain, branched or cyclic alkyl with up to 14 carbon atoms, and their physiologically acceptable salts.