Mono- and diepoxide derivatives of LL-F28249 compounds
US4876272A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1987 |
| Grant date | Oct 24, 1989 |
| Priority date | — |
| Expiry date | Mar 6, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel mono- C(26,27) and diepoxide C(14,15;26,27) derivatives of LL-F28249.alpha., .beta., .epsilon., .zeta., .theta. and .iota. compounds. The LL-F28249 compounds (collectively) are isolates from the fermentation broth of Streptomyces cyaneogriseus subspecies noncyanogenus having deposit accession number NRRL-15773. The compounds of this present invention are derived by regioselective epoxidation of 5,23-0,0-bis-silylated LL-F28249 compounds at low temperature, followed by desilylation. These novel compounds have anthelmintic, insecticidal, ectoparasiticidal, nematicidal and acaricidal activity and also are useful intermediates for the preparation of further biologically active compounds. Compositions containing these described derivatives as active ingredients thereof are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.