Quinoline compounds
US4876346A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 15, 1986 |
| Grant date | Oct 24, 1989 |
| Priority date | — |
| Expiry date | May 15, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula ##STR1## wherein X is N or CR.sup.1 PA1 Y is O, S, NR.sup.1, CHR.sup.1 or C(R.sup.1).sub.2 when n=O, or N or CR.sup.1 when n=1; PA1 p is 0-3; PA1 R.sup.1 is hydrogen or lower alkyl; PA1 R.sup.2 is H, ##STR2## --SO.sub.2 R.sup.3 or --SO.sub.2 N(R.sup.3).sub.2, lower alkyl, lower alkenyl, lower alkynyl or lower alkyl carbonyl prolinate; PA1 R.sup.3 is H, lower alkyl or perfluoro lower alkyl; PA1 R.sup.4 is lower alkyl, phenyl, pyridyl or thienyl; PA1 R.sup.5 is hydrogen, lower alkyl, phenyl or pyridyl; PA1 A is O or NR.sup.1 ; PA1 B is OR.sup.1 or N(R.sup.5).sub.2 ; PA1 m is 0-2; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.