"Process for the separation of a mixture of ""syn"" and ""anti"" oxime isomers"
US4876351A · kind A · utility
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11Claims
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Key dates
| Filing date | Oct 30, 1987 |
| Grant date | Oct 24, 1989 |
| Priority date | — |
| Expiry date | Oct 30, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/54
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the separation of a mixture of syn and anti oxime isomers one from the other which comprises adsorbing said mixed oxime isomers onto a non-functional macroreticular adsorption resin, and eluting said resin to yield at least one eluate fraction containing one of said isomers while being substantially free of the other of said isomers. The application of this process to the separation of syn and anti isomers of cephalosporin compounds possessing an oxime grouping in a side-chain in the 7.beta.-position, and of acids corresponding to this 7.beta.-side chain, is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.