Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process

US4877612A · kind A · utility

Assignee

• Frank M. Berger · US

Inventors

• Frank Berger · Leutenbach, DE
• Constantin Bona · New York, US
• Mary P. Lechevalier · Piscataway, US

Key dates

• Filing date: Sep 2, 1986
• Grant date: Oct 31, 1989
• Expiry date: Sep 2, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55594
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process is provided for preparing immunological adjuvants (which are unusual in that they do not contain mycolic acids, mycolic acid esters or lipopolysaccharides, and can increase the immune response in animals of soluble and particulate antigens without the presence of oil or oily vehicles, and without inducing adjuvant arthritis or other undesirable side effects) by solvent extraction from a species of Amycolata, a genus of filamentous branching bacteria known as Amycolata, as well as pharmaceutical compositions containing such adjuvants, and a process for increasing the immune response of antigens in animals by administration of such adjuvants.