Method of enhancing lipophile transport using cyclodextrin derivatives
US4877778A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 1, 1987 |
| Grant date | Oct 31, 1989 |
| Priority date | — |
| Expiry date | Jul 1, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0012
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
Levels of cholesterol, vitamin A, triglycerides, and other lipophiles in the human circulation can be manipulated by intravenous infusion of cyclodextrin-type compounds. The cyclodextrin-type compound should be highly soluble in water, amorphous and of only moderate molecular weight in order to be easily excreted; one preferred cyclodextrin, 2-hydroxypropyl-.beta.-cyclodextrin with an average molecular weight of 1460, is administered at doses of 0.5 g/kg x day. The serum levels of the lipophiles indicate that the infusion may serve to mobilize the lipophile from tissues, induce its excretion, and furthermore affect its homeostasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.