Chiral phosphorus compounds, a process for their manufacture and their application to the catalysis of enantioselective synthesis reactions
US4877908A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1987 |
| Grant date | Oct 31, 1989 |
| Priority date | — |
| Expiry date | Oct 13, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chiral phosphorus-containing ligands comprising at least one amine radical and at least one dihydrocarbylphosphinoxy radical of the formula W=OP (R).sub.2, in which R is a hydrocarbon radical selected from the group consisting of alkyl, aryl, and cycloalkyl radicals, wherein the ligand is selected from the group consisting of: those of the formula ##STR1## those of the formula ##STR2## those of the formula ##STR3## those of the formula ##STR4## in which formulae: R.sub.1 and R.sub.2 are selected from the group consisting of a hydrogen atom and hydrocarbon radicals; R.sub.3 and R.sub.4, which must be different from one another, are selected from the group consisting of a hydrogen atom and hydrocarbon radicals that may or may not carry at least one functional group selected from the group consisting of the alcohol, thiol, thioether, amine, imine, acid, ester, amide, and ether functional groups; and R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen atoms and hydrocarbon radicals that may or may not contain functional groups. A process for their manufacture comprises reacting an optically active amino alcohol, in a hydrocarbon solvent at a temperature between -50.d…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.