Novel human physiologically active polypeptide
US4879226A · kind A · utility
67Cited by
8References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 6, 1984 |
| Grant date | Nov 7, 1989 |
| Priority date | — |
| Expiry date | Apr 6, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/828
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A human physiologically active polypeptide, human Tumor Necrosis Factor (human TNF), comprising a specific amino acid sequence of 155 amino acid residues. The base sequence of the DNA coding for the human TNF has been determined using rabbit TNF cDNA. The human TNF can be advantageously produced on a large scale by recombinant DNA technique. The human TNF of the present invention has been found to be excellent in inducing necrosis of tumors with no toxic effect upon the normal tissues of the living body.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.