Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US4879278A · kind A · utility
65Cited by
3References
8Claims
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Key dates
| Filing date | May 16, 1989 |
| Grant date | Nov 7, 1989 |
| Priority date | — |
| Expiry date | May 16, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new cytostatic depsipeptide, designated "dolastatin 15", was isolated from the Indian Ocean shell-like mollusk Dolabella auricularia. Dolastatin 15 inhibited growth of the PS leukemia with ED.sub.50 0.0024 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 15, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 15 has the structural formula: ##STR1##
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