Analytical element and its use in a whole blood hemoglobin assay
US4880749A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 5, 1984 |
| Grant date | Nov 14, 1989 |
| Priority date | — |
| Expiry date | Jun 5, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein is an assay useful for the quantitative determination of hemoglobin in whole blood. This assay utilizes a multizone element comprising a registration zone comprising particulate barium sulfate distributed in a "blush" polymer, and a spreading zone having a void volume and an average pore size (e.g. greater than 5 microns) effective to accommodate whole blood. The element also contains an interactive composition capable of converting substantially all forms of hemoglobin into a detectable end product. One particularly useful interactive composition comprises a hemoglobin oxidizing agent (e.g. ferricyanide) and thiocyanate. Another useful interactive composition comprises an ionic surfactant, e.g. sodium octyl sulfate or sodium dodecyl sulfate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.