Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
US4880935A · kind A · utility
118Cited by
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Key dates
| Filing date | Aug 27, 1987 |
| Grant date | Nov 14, 1989 |
| Priority date | — |
| Expiry date | Aug 27, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The efficacy of immunotoxins having an antibody that recognizes a tumour associated antigen linked to a cytotoxin through a heterobifunctional agent of the disulphide type is improved by providing in the heterobifunctional agent a molecular grouping creating steric hindrance in relation to the disulphide link. This steric hindrance can be provided by a methyl substituted methylene group located in the heterobifunctional link adjacent to the disulphide bond.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.