5-alkylbenzimidazoles, method of use and pharmaceutical compositions

US4882342A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfgang von der Saal · Rosenheim, DE
• Jens-Peter Holck · Mannheim, DE
• Alfred Mertens · Schriesheim, DE
• Bernd Muller-Beckmann · Bamberg, DE
• Lothar Kling · Mannheim, DE

Key dates

• Filing date: Oct 6, 1987
• Grant date: Nov 21, 1989
• Expiry date: Oct 6, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention concerns new 5-alkylbenzimidazoles of the formula: ##STR1## wherein R.sub.1 is a phenyl ring of the formula: ##STR2## or R.sub.1 is naphthyl, heterocycle or a bicyclic heterocycle and R.sub.1 -R.sub.7 are described in claim 1. These compounds are useful for prophylaxis or treatment of heart and circulatory disease especially to increase contractility of the heart, lower blood pressure and/or influence the thrombocyte function and improve the microcirculation.