Chroman derivatives for combating thrombosis and asthma

US4882353A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Niewohner · Wermelskirchen, DE
• Franz-Peter Hoever · Cologne, DE
• Folker Lieb · Leverkusen, DE
• Hermann Oediger · Cologne, DE
• Ulrich Rosentreter · Binnen, DE
• Horst Boshagen · Haan, DE
• Elisabeth Perzborn · Wuppertal, DE
• Volker-Bernd Fiedler · Leverkusen, DE
• Friedel Seuter

Key dates

• Filing date: Oct 26, 1988
• Grant date: Nov 21, 1989
• Expiry date: Oct 26, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/68
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano, PA1 R.sup.2 and R.sup.3 are identical or different and stand for hydrogen, alkyl, cycloalkyl or aryl, PA1 R.sup.4 stands for hydroxyl, alkoxy, aryloxy, aralkoxy or for a group of the formula --NR.sup.5 R.sup.6, where PA1 R.sup.5 and R.sup.6 are identical or different and in each case denote hydrogen, alkyl, aryl or aralkyl, PA1 X denotes a direct bond or an oxygen or sulphur atom, NH or N-alkyl, and PA1 n denotes 0 or 1, and their physiologically tolerable salts. Also new intermediates of the formulas ##STR2##