Iodinated clonidine derivatives as radioactive imaging tracers

US4883649A · kind A · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Raymond E. Counsell · Ann Arbor, US
• Marcian Van Dort · Ann Arbor, US
• Richard Neubig · Scio Township, US

Key dates

• Filing date: Oct 13, 1988
• Grant date: Nov 28, 1989
• Expiry date: Oct 13, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Iodinated clonidine derivatives useful, inter alia, as a probe for identification and characterization of .alpha..sub.2 -adrenergic receptor sites and as tracers for imaging techniques such as positron emission tomography or computer assisted tomography. Binding competition studies have indicated that p-iodoclonidine, for example, is a particularly efficacious binder for .alpha..sub.2 -adrenergic sites.