Controlled drug delivery system for treatment of neural disorders
US4883666A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1987 |
| Grant date | Nov 28, 1989 |
| Priority date | — |
| Expiry date | Apr 29, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a method and composition for treatment of ischemic, metabolic, congenital, or degenerative disorders of the central or peripheral nervous system. The composition is formed by encapsulation within an implantable biocompatible polymeric device of one or more compounds which have the effect or replacing or stimulating functions of the nervous system. A variety of biocompatible polymers including both biodegradable and non-degradable polymers can be used to form the implants. An essential feature of the composition is linear release, achieved through manipulation of the polymer composition and form. The selection of the shape, size, drug, polymer, and method for implantation are determined on an individual basis according to the disorder to be treated and the individual patient response. A plethora of neurally active substances can be used to treat or manipulate neurological disorders, including Parkinson's Disease, particularly the subset which is refractory or poorly responsive to existing therapies; Alzheimer's Disease; Huntington's Disease; and trauma, such as spinal cord injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.