Wavelength-specific cytotoxic agents
US4883790A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1987 |
| Grant date | Nov 28, 1989 |
| Priority date | — |
| Expiry date | Apr 23, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2121/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-720 nanometers is useful in treating disorders which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light. The use of the Gp of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to receptor ligands or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.