Optically active carbacyclin intermediates and processes for the preparation thereof
US4885246A · kind A · utility
2Cited by
4References
6Claims
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Key dates
| Filing date | Dec 19, 1988 |
| Grant date | Dec 5, 1989 |
| Priority date | — |
| Expiry date | Dec 19, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/85
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octan-3-one , by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.