2-aryl-3-(substituted piperazinyl)-1-(1H-1,2,4-triazolyl)propanol-2-ol antifungal agents
US4885294A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1988 |
| Grant date | Dec 5, 1989 |
| Priority date | — |
| Expiry date | Nov 8, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An antifungal agent of the formula: ##STR1## wherein R is phenyl group which may be substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ; R.sup.1 is either (a) a phenyl group substituted by a group of the formula --N.dbd.CH--N(C.sub.1 -C.sub.4 alkyl).sub.2, ##STR2## or (b) a 5- or 6-membered aromatic heterocyclic group which may be benzo-fused and substituted by 1 or 2 substituents each independently selected from halo, C.sub.1 -C.sub.4 alkyl and halo-(C.sub.1 or C.sub.2 alkyl), said heterocyclic group being attached to the nitrogen atom of the piperazine ring by a carbon atom; PA1 and PA1 R.sup.2 is H or CH.sub.3 ; or an O-ester or O-ether thereof which is a C.sub.2 -C.sub.4 alkanoyl or benzoyl ester, or a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, phenyl-(C.sub.1 -C.sub.4 alkyl) or phenyl ether, said phenyl and benzoyl groups of said O-esters and O-ethers may be substituted by one or two substituents each selected from C.sub.1 -C.sub.4 alkyl, halo and halo-(C.sub.1 or C.sub.2 alkyl); or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.