Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
US4886743A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 24, 1985 |
| Grant date | Dec 12, 1989 |
| Priority date | — |
| Expiry date | Apr 24, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/117497
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention provides a reagent capable of binding to T cells and having specificity for a unique sequence within the variable region of the .beta. chain of the T cell receptor, the presence of increased number of T cells carrying the unique sequence relative to the number of T cells carrying the sequence present in a normal subject being associated with a specific disease. Specific diseases such as human cancers, e.g. lymphomas; autoimmune diseases, e.g. rheumatoid arthritis; Alzheimer's disease; infectious diseases, e.g. those caused by bacteria, yeast or parasite; or allergies, may be diagnosed as follows. A suitable sample containing T cells is obtained from a subject. The sample is contacted under appropriate conditions with such a reagent. If the subject's cells contain the unique sequence, a detectable complex is formed between the reagent and T cells which contain the sequence. By quantitatively determining the number of T cells containing the sequence present in the complex formed and comparing this number with the number of T cells carrying the sequence determined for a normal subject, the disease with which the unique sequence is associated may be diagnosed. Similar re…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.