Novel bis(2,2-dimethyl-1-aziridinyl) phosphinic amides for use in the treatment of tumors

US4886790A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Thomas J. Bardos · Snyder, US
• Michael E. Perlman · Old Saybrook, US
• Joan E. MacDiarmid · Amherst, US

Key dates

• Filing date: Mar 2, 1988
• Grant date: Dec 12, 1989
• Expiry date: Mar 2, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of inhibiting the replication of tumor cells is disclosed wherein Novel bis (2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents of the formula: ##STR1## wherein X is R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl, Y is alkyl or substituted alkyl of 1-10 carbon atoms and, Z is oxygen or sulfur is administered to tumor cells.