Circulation-active dioxyalkylenearyl-dihydropyridines

US4886816A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Gerhard Franckowiak · Wuppertal, DE
• Albrecht Marhold · Leverkusen, DE
• Martin Bechem · Wuppertal, DE
• Rainer Gross · Wuppertal, DE
• Michael Kayser · Hagen, DE
• Matthias Schramm · Cologne, DE
• Gunther Thomas · Wuppertal, DE

Key dates

• Filing date: May 5, 1988
• Grant date: Dec 12, 1989
• Expiry date: May 5, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is H, CN, NO.sub.2 or --COOR.sup.7, PA0 R.sup.7 is H, alkyl or various other radicals, PA0 R.sup.2 and R.sup.4 each independently is alkyl or other radicals, PA0 R.sup.3 is H or optionally substituted alkyl, PA0 R.sup.5 completes a keto or ester group, and PA0 R.sup.6 is a direct bond or --CF.sub.2 -- or --CHF--, and physiologically acceptable salts thereof.