Dihydropyridine combination product comprising a dihydropyridine compound and a cardioactive nitrate

US4886820A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rainer Gross · Wuppertal, DE
• Matthias Schramm · Cologne, DE

Key dates

• Filing date: Nov 3, 1988
• Grant date: Dec 12, 1989
• Expiry date: Nov 3, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid medicament formulation which can be administered orally, comprising 1 to 40 mg of a dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.3 are always different from one another and represent alkyl which has 1 to 12 carbon atoms and which is optionally substituted once or several times by fluorine or chlorine or which is optionally interrupted by an oxygen atom in the chain, and PA1 A represents the radical ##STR2## R.sup.2 representing one or two substituents from the group consisting of nitro, chlorine and trifluoromethyl, or represents and 0.1 to 100 mg of a cardioactive nitrate. The composition is cardio-active and the patient's tendency toward nitrate tolerance is reduced.