23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4886829A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1987 |
| Grant date | Dec 12, 1989 |
| Priority date | — |
| Expiry date | Mar 6, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/01
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel 23-oxo (keto) and 23-imino derivatives of certain C(26,27)-epoxy- and C(14,15;26,27)-diepoxy-LL-F28249 compounds. The LL-F28249 compounds (collectively) are isolates from the fermentation broth of Streptomyces cyaneogriseus subspecies noncyanogenus having deposit accession no. NRRL-15773. The derivatives are obtained by oxidation of the 23-hydroxy group of 5-O-silylated-C(26,27)-epoxy and C(14,15;26,27)diepoxy-LL-F28249 compounds, followed by desilylation and derivatization with amino compounds. The novel compounds have anthelmintic, ectoparasiticidal, nematicidal, insecticidal and acaricidal activity and are, therefore, useful in the treatment of infections in warm-blooded animals and infestations in agricultural crops. Compositions containing the present compounds as active ingredients thereof also are presented.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.