Cyanoguanidine derivative and process for preparation thereof
US4886910A · kind A · utility
4Cited by
1References
4Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 17, 1988 |
| Grant date | Dec 12, 1989 |
| Priority date | — |
| Expiry date | Feb 17, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-gua nidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.