Controlled drug delivery high molecular weight polyanhydrides
US4888176A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 12, 1987 |
| Grant date | Dec 19, 1989 |
| Priority date | — |
| Expiry date | Jun 12, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/58
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A bioerodible controlled drug release device is produced as a homogeneous polymeric matrix from a high molecular weight polyanhydride and a suitable biologically active substance. The high molecular weight polyanhydride is defined by a molecular weight greater than 20,000 and an intrinsic viscosity greater than 0.3 dl/g. The controlled drug release device is preferrably formed by solvent casting with the biologically active substance and exhibits zero order release, improved correlation between the rate of release and polymer degradation, and an induction period between introduction to the eroding environment and the initial release of the biologically active substance. The controlled drug release devices are stable for extended periods of time, flexible and durable and not subject to fracture and disintegration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.